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. 2015 Nov 5;10(11):e0141082. doi: 10.1371/journal.pone.0141082

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© 2015 Renga et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — Gpbar1^+/+ and Gpbar1^-/- mice administered L-methionine for 4 weeks were randomized to receive BAR501 (20 mg/Kg daily by gavage) or vehicle (distilled water). Effect of BAR501 on (A) portal pressure, (B) ET-1 mRNA, (C) CBS mRNA, (D) CSE mRNA, (E) eNOS mRNA, (F) iNOS mRNA and (G) CAV-1. Results are the mean ± SE of 4–8 mice per group. *p<0.05 versus pbar1^+/+ mice. #p<0.05 versus Gpbar1 ^+/+ mice fed methionine. °p<0.05 versus Gpbar1^-/- mice. °°p<0.05 versus Gpbar1^-/- mice fed methionine.