Figure 1.

Cytotoxic effect of As₄S₄ in combination with JQ1 on gastric and colon cancer cells.

Notes: (A) AGS cells were treated with As₄S₄ 1.5 μM alone or in combination with JQ1 (1 or 10 μM) for 48 hours. (B) MGC803 cells were treated with As₄S₄ 1 μM alone or in combination with JQ1 1 μM for 48 hours. (C) SW480 cells were treated with As₄S₄ 5 μM alone or in combination with JQ1 1 μM for 48 hours. (D and E) HCT116 cells were treated with As₄S₄ 5 μM alone or in combination with JQ1 (1.0 or 10 μM) for 24 and 48 hours. Data represent the mean ± standard deviation of three independent experiments and the relative cell viability was expressed as the percentage of untreated well. ^**P<0.01, ^***P<0.001.

Abbreviations: As₄S₄, arsenic sulfide; h, hours.