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. 2015 Oct 30;8:771–780. doi: 10.2147/JPR.S88203

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© 2015 Webster et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Patient disposition in the RCT (A) and OLT (B).

Notes: Adapted from Michna E, Blonsky ER, Schulman S, et al. Subcutaneous methylnal trexone for treatment of opioid-induced constipation in patients with chronic, nonmalignant pain: a randomized controlled study. J Pain. 2011;12(5):554–562.¹³ Copyright © 2011, with permission from Elsevier. Additional study data was also used.

Abbreviations: mITT, modified intention-to-treat; OLT, open-label trial; prn, as needed; qd, once daily; qod, every other day; RCT, randomized controlled trial.