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. 2015 Jun 6;13:187. doi: 10.1186/s12967-015-0547-4

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© Hanes et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histopathology of infarcted versus normal myocardium. Hematoxylin and eosin staining of representative infarcted areas demonstrated a heterogenous area of dense, fibrous, connective tissue intermixed with islets of intact cardiomyocytes (a). Microsphere silhouettes were visualized occluding small arteries and arterioles shown here as stain filling defects (b). Further evaluation with Picro Sirius stain revealed a large amount of disorganized collagen deposition and perifiber fibrosis in the infarcted region denoted by the deeply red staining sections (c), when compared to normal myocardium (d). Evaluation of VVG stained slides demonstrated hyperplasia of the arterial walls, particularly in the media and adventitial layers (e) when compared to normal arteries (f).