Table 3. Predictors for the incidence of death/stroke/SE in patients without OAC; Univariate and multivariate analysis.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | p value | HR (95% CI) | p value |
| <Baseline characteristics> | ||||
| Female sex | 1.12 (0.88–1.43) | 0.34 | 0.81 (0.62–1.06) | 0.13 |
| Advanced age (≥75 years) | 2.93 (2.25–3.84) | <0.01 | 1.68 (1.24–2.29) | <0.01 |
| Underweight (BMI <18.5 kg/m2) | 2.76 (2.08–3.64) | <0.01 | 1.71 (1.25–2.32) | <0.01 |
| Paroxysmal atrial fibrillation | 0.59 (0.46–0.75) | <0.01 | 0.84 (0.64–1.11) | 0.22 |
| Antiplatelet therapy at baseline | 1.09 (0.85–1.39) | 0.50 | 0.83 (0.62–1.09) | 0.18 |
| <Co-morbidities> | ||||
| Previous stroke/SE/TIA | 2.41 (1.83–3.14) | <0.01 | 1.70 (1.25–2.30) | <0.01 |
| Heart failure | 3.05 (2.38–3.89) | <0.01 | 1.59 (1.17–2.15) | <0.01 |
| Hypertension | 0.88 (0.70–1.13) | 0.32 | 0.81 (0.62–1.05) | 0.11 |
| Diabetes mellitus | 1.18 (0.89–1.55) | 0.24 | 0.99 (0.72–1.34) | 0.96 |
| Dyslipidemia | 0.69 (0.53–0.88) | <0.01 | 0.90 (0.68–1.19) | 0.48 |
| Coronary artery disease | 1.23 (0.90–1.66) | 0.19 | 0.89 (0.62–1.27) | 0.54 |
| Valvular heart disease | 2.04 (1.51–2.71) | <0.01 | 1.05 (0.75–1.46) | 0.76 |
| Cardiomyopathy | 0.38 (0.06–1.19) | 0.11 | 0.37 (0.06–1.17) | 0.10 |
| Peripheral artery disease | 1.95 (1.17–3.05) | 0.01 | 1.38 (0.80–2.23) | 0.24 |
| Chronic kidney disease | 2.70 (2.13–3.43) | <0.01 | 1.53 (1.16–2.02) | <0.01 |
| Anemia | 3.93 (3.04–5.12) | <0.01 | 2.41 (1.78–3.28) | <0.01 |
| COPD | 1.44 (0.83–2.30) | 0.18 | 1.06 (0.60–1.75) | 0.83 |
| History of major bleeding | 1.62 (0.83–2.82) | 0.15 | 0.84 (0.41–1.52) | 0.58 |
SE: systemic embolism, HR: hazard ratio, CI: confidence interval, BMI: body mass index, TIA: transient ischemic attack, COPD: chronic obstructive pulmonary disease.