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. Author manuscript; available in PMC: 2016 Jun 25.
Published in final edited form as: J Med Chem. 2015 Jun 5;58(12):5038–5052. doi: 10.1021/acs.jmedchem.5b00426

Figure 5.

Figure 5

(+)-N-Hexylnoroxymorphone 1d inhibits LPS induced NO over-production in a dose-dependent manner. (+)-Naltrexone 1a served as the control compound for comparison. BV-2 cells were treated with 200 ng/mL LPS and various concentrations of test compounds for 24 h. NO in the supernatant was measured by the 2,3-diaminonaphthalene method.6, 29 The NO in the LPS (200 ng/mL) control group was normalized to 100%.