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(+)-Didesoxy-N-hexylnoroxymorphone 6 inhibits LPS induced NO over-production in a dose-dependent manner. (+)-Naltrexone 1a served as the control compound for comparison. BV-2 cells were treated with 200 ng/mL LPS and various concentrations of test compounds for 24 h. NO in the supernatant was measured by the 2,3-diaminonaphthalene method.6, 29 The NO in the LPS (200 ng/mL) group was normalized to 100%.
