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. Author manuscript; available in PMC: 2016 Jun 25.
Published in final edited form as: J Med Chem. 2015 Jun 5;58(12):5038–5052. doi: 10.1021/acs.jmedchem.5b00426

Table 1.

IC50 Values of (+)-Naltrexone 1a, (+)-β-Naltrexol 2, (+)-α-Naltrexol 3, and (+)-10-Nornaltrexone 7

Compound IC50 of NO (μM) IC50 of viability (μM)
graphic file with name nihms733807t1.jpg 105.5 ± 10.1 > 400
graphic file with name nihms733807t2.jpg 242.8 ± 21.3 > 400
graphic file with name nihms733807t3.jpg 143.5 ± 20.8 > 400
graphic file with name nihms733807t4.jpg 76.2 ± 27.2 > 400