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. Author manuscript; available in PMC: 2016 Jun 25.
Published in final edited form as: J Med Chem. 2015 Jun 5;58(12):5038–5052. doi: 10.1021/acs.jmedchem.5b00426

Table 2.

IC50 Values of (+)-N-Alkylnoroxymorphone Analogs 1b–1k.

graphic file with name nihms733807u2.jpg IC50 of NO (μM) IC50 of viability (μM)
graphic file with name nihms733807t5.jpg 24.8 ± 3.4 > 200
graphic file with name nihms733807t6.jpg 7.5 ± 1.7 > 200
graphic file with name nihms733807t7.jpg 6.7 ± 0.4 121.4 ± 7.3
graphic file with name nihms733807t8.jpg 3.0 ± 0.2 68.5 ± 2.8
graphic file with name nihms733807t9.jpg 1.7 ± 0.1 33.4 ± 1.0
graphic file with name nihms733807t10.jpg 1.7 ± 0.4 26.8 ± 0.4
graphic file with name nihms733807t11.jpg 1.2 ± 0.2 37.1 ± 1.9
graphic file with name nihms733807t12.jpg 1.4 ± 0.2 69.3 ± 3.4
graphic file with name nihms733807t13.jpg 1.4 ± 0.3 140.8 ± 5.5
graphic file with name nihms733807t14.jpg 1.8 ± 0.2 65.7 ± 3.3