Table 1. Participant Characteristics by Cognitive Complaint Category.
| No Complaint | Self-Only Complaint | Informant-Only Complaint | Mutual Complaint | p-value | |
|---|---|---|---|---|---|
| Sample size, n | 18 | 23 | 19 | 59 | |
| Age at death, mean (SD), y | 86.8 (9.3) | 90.6 (5.3) | 86.7 (10.7) | 87.1 (8.3) | 0.45 |
| Sex, % female | 56 | 65 | 53 | 44 | 0.37 |
| Race, % White | 89 | 96 | 100 | 93 | 0.52 |
| Education, mean (SD), y | 14.6 (2.3) | 14.0 (4.2) | 16.4 (1.6) | 15.6 (3.0) | 0.05 |
| MMSE score † , mean (SD) | 26.5 (3.8) | 26.7 (1.8) | 25.1 (3.3) | 26.3 (2.8) | 0.24 |
| Time from last visit to death ‡ , mean (SD), years | 0.9 (0.5) | 0.9 (0.5) | 0.8 (0.5) | 0.8 (0.5) | 0.97 |
| Length of time with MCI diagnosis, mean (SD), years | 2.4 (2.1) | 2.7 (2.3) | 3.3 (1.5) | 4.8 (3.1) | 0.003 * |
| APOE, % e4 positive | 29 | 33 | 56 | 32 | 0.31 |
| Depression, mean (SD) | 3.1 (2.3) | 2.5 (1.6) | 2.2 (2.5) | 3.2 (2.7) | 0.39 |
| MCI diagnosis subtype | 0.25 | ||||
| Amnestic, Single Domain, n (%) | 5 (28) | 10 (43) | 7 (37) | 19 (32) | |
| Amnestic, Multiple Domain, n (%) | 6 (33) | 7 (30) | 10 (53) | 26 (44) | |
| Non-Amnestic, Single Domain, n (%) | 6 (33) | 2 (9) | 2 (11) | 10 (17) | |
| Non-Amnestic, Multiple Domain, n (%) | 1 (6) | 4 (17) | 0 (0) | 4 (7) | |
| Primary Neuropathological Diagnosis | |||||
| Normal Brain, n (%) | 4 (29) | 2 (12) | 3 (25) | 4 (9) | 0.24 |
| Alzheimer’s Disease, n (%) | 3 (21) | 9 (41) | 8 (51) | 25 (49) | 0.29 |
| Vascular Disease, n (%) | 2 (15) | 4 (22) | 2 (14) | 7 (16) | 0.93 |
| Lewy Body Disease, n (%) | 1 (8) | 1 (6) | 0 (0) | 2 (5) | 0.81 |
| Frontotemporal Dementia, n (%) | 1 (8) | 0 (0) | 0 (0) | 3 (7) | 0.51 |
| Hippocampal Sclerosis, n (%) | 0 (0) | 1 (6) | 0 (0) | 0 (0) | 0.28 |
| NIA/Reagan Institute | 0.02 * | ||||
| High likelihood AD, % yes | 6 | 0 | 16 | 24 | |
| Intermediate likelihood AD, % yes | 18 | 59 | 42 | 38 | |
| Low likelihood AD, % yes | 24 | 27 | 26 | 16 | |
| Criteria not met, % yes | 53 | 14 | 16 | 22 | |
| CERAD Criteria | 0.15 | ||||
| Definite AD (%) | 8 | 0 | 12 | 27 | |
| Probable AD (%) | 0 | 17 | 25 | 25 | |
| Possible AD (%) | 23 | 25 | 25 | 11 | |
| Criteria not met (%) | 69 | 58 | 38 | 36 | |
| Braak Stages | 0.31 | ||||
| Stage 0 | 6 | 0 | 0 | 2 | |
| Stage I | 24 | 5 | 11 | 3 | |
| Stage II | 29 | 23 | 16 | 17 | |
| Stage III | 18 | 32 | 21 | 22 | |
| Stage IV | 18 | 32 | 32 | 33 | |
| Stage V | 0 | 9 | 5 | 16 | |
| Stage VI | 6 | 0 | 16 | 7 | |
| Neuritic plaques | 0.03 * | ||||
| None | 50 | 14 | 21 | 24 | |
| Sparse | 28 | 36 | 47 | 15 | |
| Moderate | 17 | 32 | 16 | 39 | |
| Frequent | 6 | 18 | 16 | 22 | |
| Diffuse plaques | <0.01 * | ||||
| None | 40 | 16 | 18 | 13 | |
| Sparse | 40 | 42 | 47 | 15 | |
| Moderate | 7 | 11 | 0 | 34 | |
| Frequent | 13 | 32 | 35 | 38 |
Note: Complaint categories are mutually exclusive and defined based on clinician-facilitated interviews with the participant and informant; depression assessed by the Geriatric Depression Scale excluding the cognitive complaint question; MMSE = Mini-Mental State Examination;
*p<0.05;
†MMSE score range from 0–30 with lower score = worse performance;
‡Follow-up period is time from the last clinic visit to death.