Fig 4. Cardiomyocyte-specific IKK/NF-κB activation induces myofiber degeneration and loss of typical cardiomyocyte proteins.

(A) Control and IKK^MyHC sections were stained for sarcomeric α-actinin (green) and DAPI (blue). Scale bar: 100 μm. (B) Control and IKK^MyHC sections were stained for desmin (yellow) and DAPI (blue). Scale bar: 100 μm. (C) Electron microscopic analyses of control and IKK^MyHC heart sections. Cardiomyocytes of control animals show normally developed myofibers with typical sarcomeres (left). IKK^MyHC cardiomyocytes show general disorganization and a reduced width of myofibers (right). Scale bar: 1 μm.