Fig 5. Effects of CaCC inhibitors on basal and Ace-stimulated short circuit current (Isc) in mouse tissue by Ussing chamber experiment, as described in the Materials and Methods.
Basal (unstimulated) and Ace stimulated Isc was measured in the absence (control) and presence of (A) CaCCinh-A01 and (B) tannic acid. Two different concentrations of small molecules, low (5 μM) and high (100 μM), were used in each case and pre-incubated luminally before being treated with Ace toxin to the luminal side of the tissue. Results represent mean ± SEM of 6 tissue pairs; NS indicates the difference is not significant.