Table 2. Secondary structural content of native Ace and Ace-CaCC inhibitor complexes † .
Ace alone | Ace + tannic acid | Ace + DGA | Ace + CaCCinh-A01 | |
---|---|---|---|---|
θ 222 | -17.3 ± 0.8 | -3.5 ± 0.8 | -26.5 ± 0.7 | -36.0 ± 0.5 |
α-helix (%) | 43.0 ± 2.7 | 21.3 ± 1.6 | 55.4 ± 1.1 | 63.7 ± 1.8 |
Random coil (%) | 26.5 ± 2.6 | 44.2 ± 1.5 | 19.7 ± 0.8 | 15.8 ± 0.7 |
†Data were deconvoluted using CDNN software (http://thelab.photophysics.com/circular-dichroism/protein-secondary-structure-analysitools-cdnn/).