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. Author manuscript; available in PMC: 2016 Nov 3.
Published in final edited form as: Structure. 2015 Oct 1;23(11):2099–2110. doi: 10.1016/j.str.2015.08.013

Figure 5. ProMMP-7 binds plasma membranes and internalized vesicles of live colon cancer cells by the interface present in both NMR structures.

Figure 5

Confocal images of human colon adenocarcinoma COLO 205 cells were acquired after incubating 5 min. at 37 °C with proMMP-7 labeled wi th IANBD at Y96C (top row) or the non-interacting S206C site (bottom row). The external surface of the plasma membrane emits red from wheat germ agglutinin conjugated to Alexa Fluor 594 (WGA-AF594). The dashed blue lines delimit the cell nuclei stained by Hoechst 33342 (not shown). Scale bar, 10 μm.