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. Author manuscript; available in PMC: 2016 Nov 3.
Published in final edited form as: Cell Metab. 2015 Oct 1;22(5):922–935. doi: 10.1016/j.cmet.2015.09.001

Fig. 5. AMPK consensus motif and substrate sequence alignment.

Fig. 5

AMPK consensus motif derived from (Gwinn et al., 2008) with multiple sequence alignment of exercise-regulated phosphosites in human muscle (Human Exercise) is displayed. The alignment shows: known AMPK substrates (black circles); internally predicted AMPK substrates with validation (blue circles) in either AICAR stimulated Rat L6 myotubes (Rat AICAR) or global AMPK in vitro kinase analysis in HEK lysates (black diamonds ◆); and externally predicted AMPK substrates from (Banko et al., 2011) (orange circles).