. Author manuscript; available in PMC: 2017 Jan 1.

Published in final edited form as: Transl Res. 2015 May 5;167(1):183–191. doi: 10.1016/j.trsl.2015.04.015

TABLE 1.

Models of Acute Lung Injury in Rodents^*

Chief Target	Injury-causing Agent	Usual Route of Delivery
1. Capillary endothelium	a. Oleicacid	i.v.
	b. LPS	i.t.
	c. Bleomycin	i.t.
	d. E. coli (live)	i.t. or aerosol
2. Alveolar epithelium	e. HCl	i.t.
	f. Hyperoxia (100% O₂)	airway
	g. Surfactant depletion	repetitive BAL
	h. Mechanical ventilation	airway intubation
	i. Bleomycin	i.t.
	j. FITC	i.t.
	k. Diphtheria toxin	i.p.
3. Both endothelial and alveolar epithelial cells	l. Ischemia-reperfusion (IR) injury	local (lung) pulmonary artery occlusion or distal IR injury
	m. Sepsis (LPS, CLP, live bacteria)	i.t., i.v., i.p.
	n. Other conditions (hemorrhagic shock or “double-hit sepsis”, hemorrhagic shock followed by CLP)	variable

Based in part on published reviews, including Bernard GR, et al. The American-European Consensus Conference on ARDS. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818–24.