1. Anti-inflammatory |
a. Low dose hydrocortisone |
Multi-center Phase II/III RCT |
Mortality, ARDS severity |
|
b. Vitamin C |
Multi-center Phase II RCT |
ARDS severity |
|
c. Vitamin D |
Phase I/II RCT |
Prevention of ARDS |
2. Growth factors |
d. GM-CSF |
Multi-center Phase III RCT (planned) |
Mortality, prevention and severity of ARDS |
3. Coagulation/complement cascade |
e. Nebulized heparin |
Multi-center Phase II RCT |
Prevention and severity of ARDS |
|
f. Aspirin (LIPS-A) |
Multi-center Phase II RCT |
ARDS prevention, mortality |
4. Stem cell therapy |
g. Allogeneic MSC infusion |
Multi-center Phase I/II open label, dose escalation |
Safety, ARDS severity |