Figure 6.
A, Example broadband LFP traces of theta oscillations for m1, used to generate comodulograms in B. B, Comodulogram showing the MI for each phase frequency by amplitude envelope frequency. The left plot used 2000 ms segments of theta events; the right plot used 600 ms of signal around SWR events, concatenated across events for sufficient phase-bin sampling (see Materials and Methods). C, The probability of spiking was greater for SWR than for ε events. Bars show firing probability during peak SWR, ε80–120, and ε110–160 windows, for CS and IN cells, following same methods as in Figure 4; SWR bars are also shown in Figure 4, duplicated here for comparison to ε events. Error bars reflect 95% confidence intervals. D, Events were clustered based on their NMF feature weights (see Materials and Methods). Middle plot shows the comparison of original group labels (SWR, high ε, low ε) by unsupervised clustering of all high-frequency events. Cluster position is defined by the percentage of members from each original group, with each group assigned to one axis, red–green–blue color-coded by axis position. Raw traces of the events that were closest to the center of their clusters are shown in the color corresponding to their cluster, with proportion of group representation shown below the trace. Dark-gray, gray, and light-gray spheres correspond to p < 0.5, p < 0.01, and p < 0.001 significance rate boundaries, respectively.