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. 2015 Nov 4;35(44):14783–14793. doi: 10.1523/JNEUROSCI.2980-15.2015

Figure 3.

Figure 3.

ROS production by infiltrating neutrophils is decreased in CD36-null hosts. A–C, Brain leukocytes (A), monocytes/macrophages (B), and neutrophils (C) producing ROS measured by in vivo DHE staining and flow cytometry 72 h after MCAo in CD36 chimeric mice (n = 4 or 5 mice/group). The number of neutrophils producing ROS is reduced in the CD36 KO host accounting for the decrease of the ROS-positive leukocytes. Values are mean ± SE. *p < 0.05 versus WT host→WT BM. D, E, Median fluorescence intensity (MFI) of DHE signals analyzed by flow cytometry of in brain leukocytes (D), monocytes/macrophages (E), and neutrophils (F) (n = 4 or 5 mice/group). DHE MFI is proportional to the amount of cellular ROS. Values are mean ± SE. *p < 0.05 versus WT host→WT BM.