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. 2015 Nov 4;35(44):14794–14808. doi: 10.1523/JNEUROSCI.1295-15.2015

Figure 9.

Figure 9.

Model. A, During development, TCPTc growth cones are exposed to 5-HT from raphe nuclei axon projections. 5-HT activates htr2ab in the TCPTc, decreasing expression of ephrinB2a and allowing axons to cross the midline. B, When 5-HT signaling is inhibited by drug, knock-down, or hypoxia, the up-regulation of ephrinB2a expression prevents TCPTc axons crossing the midline.