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. 2015 Nov 4;35(44):14861–14871. doi: 10.1523/JNEUROSCI.4968-14.2015

Figure 5.

Figure 5.

Fbxw7 function limits myelin sheath length. A–D, Confocal microscope images of single oligodendrocytes in spinal cords of 6 dpf larvae. Brackets indicate examples of myelin sheaths. Oligodendrocytes in A and C express EGFP-CaaX and those in B and D express dominant-negative Fbxw7 and EGFP-CaaX. E, Graph showing average sheath lengths. n = 145 sheaths from 22 control oligodendrocytes in wild-type larvae, 187 sheaths from 24 dnFbxw7-expressing oligodendrocytes in wild-type larvae, 88 sheaths from 9 control oligodendrocytes in mtor−/− larvae and 41 sheaths from 3 dnFbxw7-expressing oligodendrocytes in mtor−/− larvae. **p = 0.0012, ****p < 0.0001, two-tailed Mann–Whitney test. ns, Not significant.