Table 1.
GO term analysis of microarray profile after REST knockdown
| Biological process | p | Benjamini | Cellular component/molecular process | p | Benjamini |
|---|---|---|---|---|---|
| Cellular component | |||||
| Transmission of nerve impulse | 1.20E-06 | 3.70E-04 | Synapse | 2.10E-06 | 3.90E-04 |
| Secretion by cell | 1.30E-06 | 3.30E-04 | Cell junction | 6.30E-04 | 1.70E-02 |
| Cell–cell signaling | 7.00E-06 | 1.50E-03 | Cytoplasmic vesicle | 1.60E-03 | 2.60E-02 |
| Neurotransmitter transport | 8.20E-06 | 1.50E-03 | Neuron projection | 5.30E-03 | 6.90E-02 |
| Exocytosis | 1.90E-04 | 2.30E-02 | Synaptosome | 8.30E-03 | 9.30E-02 |
| Cell projection organization | 3.30E-04 | 3.70E-02 | |||
| Neuron differentiation | 8.10E-04 | 7.70E-02 | |||
| Regulation of neuronal synaptic plasticity | 1.60E-03 | 1.20E-01 | |||
| Intracellular signaling cascade | 2.70E-03 | 1.80E-01 | Molecular process | ||
| MAPKKK cascade | 3.50E-03 | 2.10E-01 | SNARE binding | 3.80E-05 | 1.10E-02 |
| Cell surface receptor linked signal transduction | 5.80E-03 | 3.00E-01 | Syntaxin binding | 2.90E-04 | 2.80E-02 |
| Synaptic vesicle transport | 8.40E-03 | 3.90E-01 | Nucleotide receptor activity | 2.40E-03 | 1.60E-01 |
| Stress-activated protein kinase signaling pathway | 9.60E-03 | 4.00E-01 | Cytoskeletal protein binding | 7.80E-03 | 3.70E-01 |
| Behavior | 1.20E-02 | 4.50E-01 | Calcium ion binding | 1.00E-02 | 4.00E-01 |
| Chemical homeostasis | 1.20E-02 | 4.50E-01 | Magnesium ion binding | 1.20E-02 | 4.00E-01 |
| Axonogenesis | 1.20E-02 | 4.40E-01 | Nucleotide receptor activity, G-protein coupled | 2.20E-02 | 5.10E-01 |
| Vesicle-mediated transport | 1.50E-02 | 4.90E-01 | Gated channel activity | 2.30E-02 | 4.90E-01 |
| Cell morphogenesis involved in neuron differentiation | 2.00E-02 | 5.70E-01 | Ion channel activity | 2.50E-02 | 4.50E-01 |
| Protein kinase cascade | 2.00E-02 | 5.60E-01 | Substrate specific channel activity | 2.90E-02 | 4.50E-01 |
| Regulation of membrane potential | 2.10E-02 | 5.60E-01 | |||
| Cellular component | |||||
| Response to wounding | 4.10E-05 | 5.20E-02 | Extracellular space | 3.60E-05 | 6.20E-03 |
| Taxis | 5.50E-05 | 3.50E-02 | Extracellular region part | 4.10E-05 | 3.50E-03 |
| Locomotory behavior | 1.80E-04 | 7.50E-02 | Proteinaceous extracellular matrix | 5.70E-02 | 9.20E-01 |
| Regeneration | 4.70E-04 | 1.40E-01 | Extracellular matrix | 9.40E-02 | 9.70E-01 |
| Behavior | 4.90E-04 | 1.20E-01 | Endoplasmic reticulum | 9.90E-02 | 9.50E-01 |
| Response to glucocorticoid stimulus | 6.60E-04 | 1.30E-01 | |||
| Response to organic cyclic substance | 9.00E-04 | 1.50E-01 | |||
| Response to corticosteroid stimulus | 9.20E-04 | 1.40E-01 | Molecular process | ||
| Cell motion | 1.30E-03 | 1.70E-01 | Cytokine activity | 1.50E-03 | 1.40E-01 |
| Response to mechanical stimulus | 2.20E-03 | 2.30E-01 | Olfactory receptor activity | 9.50E-03 | 5.10E-01 |
| Neuron differentiation | 3.00E-03 | 2.80E-01 | Calcium ion binding | 1.90E-02 | 7.00E-01 |
| Bone development | 3.50E-03 | 2.80E-01 | Glutathione transferase activity | 3.40E-02 | 7.80E-01 |
| Immune response | 3.70E-03 | 2.80E-01 | O-acyltransferase activity | 5.00E-02 | 8.30E-01 |
| Inflammatory response | 4.20E-03 | 2.90E-01 | Enzyme inhibitor activity | 5.30E-02 | 8.10E-01 |
| Positive regulation of anti-apoptosis | 4.30E-03 | 2.80E-01 | Growth factor activity | 6.60E-02 | 8.20E-01 |
| Regulation of cell proliferation | 5.30E-03 | 3.10E-01 | Metalloenzyme Regulator activity | 7.60E-02 | 8.40E-01 |
| Detection of stimulus | 5.60E-03 | 3.00E-01 | Endopeptidase inhibitor activity | 8.60E-02 | 8.60E-01 |
| Detection of chemical stimulus | 6.00E-03 | 3.10E-01 | Carbohydrate binding | 8.70E-02 | 8.40E-01 |
| Cognition | 7.20E-03 | 3.50E-01 | |||
| Biological adhesion | 8.80E-03 | 3.70E-01 |