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. 2015 Nov 4;35(44):14922–14942. doi: 10.1523/JNEUROSCI.1897-15.2015

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Copyright © 2015 the authors 0270-6474/15/3514923-21$15.00/0

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Figure 11. — Model for cellular specificity of Kv2 paralog expression in L5 pyramidal neurons of cerebral cortex. L5a IT pyramidal projection neurons are negative for Ctip2 but positive for Etv1-EGFP and a contralaterally placed tracer in striatum and express high levels of both Kv2.1 and Kv2.2. In contrast, L5b PT pyramidal projection neurons are positive for Ctip2 and Glt-EGFP but negative for a contralaterally placed tracer in striatum and express high levels of Kv2.1 but low levels of, to no, Kv2.2. MSN, Striatal medium spiny neuron. Levels of Kv2.1 and Kv2.2 in the different pyramidal cell classes are a simplified representation meant to convey the overall differences in Kv2.1 and Kv2.2 expression levels across the population of IT and PT neurons studied here and do not account for variations within the population of IT and PT cells.