Table 1.
Recommendations for the management of hepatitis B and C infection after liver or kidney transplantation
| Chronic hepatitis B | Post-liver transplantation | Prophylaxis and treatment | HBIG (for short term) plus NA1 |
| Post-kidney transplantation | NAs1 | ||
| Chronic hepatitis C | Post-liver transplantation | No prophylaxis | Sofosbuvir based regimens or “3D” regimen plus RBV (for genotypes 1 and 4) |
| Post-kidney transplantation | Newer direct oral antivirals plus/minus RBV (studies are ongoing)2 |
1
Frontline analogues are considered entecavir or tenofovir in renal proper doses (consider telbivudine in the presence of renal dysfunction);
2
Interferon is contraindicated due to the high risk of allograft rejection. HBIG: Hepatitis B immune globulin; NAs: Nucleos(t)ide analogues; 3D: Paritaprevir (plus ritonavir)/ombitasvir/dasabuvir for genotype 1 and paritaprevir (plus ritonavir)/ombitasvir for genotype 4; RBV: Ribavirin.