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Structure of botulinum toxin A. The Cα backbone is represented as ribbons with the LC in cyan, the HN in dark blue and the HC in a green to yellow gradient highlighting the HCN and HCC subdomains. The HN belt is in red. HN + HC: 100 kDa heavy chain; HN: 50 kDa amino terminus; HC: 50 kDa carboxy terminal of the heavy chain; HCC: β-beta tree foil fold heavy chain subdomain; HCN: β-sheet jelly roll fold heavy chain subdomain; LC: Light chain. Adapted with permission from Montal[17].
