Table 2.
Diagnostic criteria for celiac disease proposed by Catassi and Fasano[22]
| The presence of signs and symptoms compatible with celiac disease |
| Positivity of serum celiac disease IgA class autoantibodies at high titer |
| Presence of the predisposing genes HLA-DQ2 and/or -DQ8 |
| Celiac enteropathy at the small intestinal biopsy1 |
| Resolution of the symptoms and normalization of serology test following the implementation of a gluten-free diet2 |
1
Including Marsh-Oberhuber 3 lesions, Marsh-Oberhuber 1-2 lesions associated with positive celiac antibodies positive at low/high titer, or Marsh-Oberhuber 1-3 lesion associated with IgA subepithelial deposits;
2
Histological normalization in patients with sero-negative celiac disease or associated IgA deficiency. At least 4 of 5 (or 3 of 4 if the HLA genotype is not performed). HLA: Human leukocyte antigen.