Figure 1.

Effect of treatment with a Prunella vulgaris ethanolic extract on the onset of colitis in mdr1a^-/- mice. Mdr1a^-/- mice were removed from the study as they developed severe clinical disease (e.g., > 15% weight loss) before the termination of the experiment as described in Materials and Methods. ^aP < 0.05, as compared to FVB^WT control mice. Vehicle-treated mdr1a^-/- mice n = 16, metronidazole-treated mdr1a^-/- mice n = 10, Prunella vulgaris-treated mdr1a^-/- mice n = 13. This survival (i.e., mice remaining on study) curve is representative of two independent experiments.