Figure 2.

Oral administration of a Prunella vulgaris extract attenuated both microscopic and macroscopic cecal lesions in mdr1a^-/- mice. A: Representative photographs of ceca and colons (left) and representative photomicrographs (200 ×) of histological sections of ceca (right) collected at necropsy from FVB^WT or mdr1a^-/- mice treated with either vehicle or Prunella vulgaris (P. vulgaris) extract; B: Colon lengths were measured at necropsy and the group range is represented. Whiskers indicate minimum and maximum values, while the horizontal line represents the group median; C: Macroscopic typhlocolitic scores were assigned at necropsy as described in the Materials and Methods (Max/Severe = 9, Min/Healthy = 0). ^aP < 0.05, ^bP < 0.01 compared to mdr1a^-/- vehicle as calculated by Kruskal-Wallis test. Vehicle-treated FVB^WT mice n = 6, vehicle-treated mdr1a^-/- mice n = 16, P. vulgaris-treated mdr1a^-/- mice n = 13.