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Administration of a Prunella vulgaris ethanolic extract reduced local myeloperoxidase activity in the colon of mdr1a-/- mice. Homogenates of colonic tissue were subjected to an assay for MPO activity. aP < 0.05, bP < 0.01 compared to mdr1a-/- vehicle as calculated by Kruskal-Wallis test. Vehicle-treated FVBWT mice n = 6, vehicle-treated mdr1a-/- mice n = 10, P. vulgaris-treated mdr1a-/- mice n = 7. MPO: Myeloperoxidase; P. vulgaris: Prunella vulgaris.
