Table 3.
Attenuation of inflammatory gene expression in mdr1a-/- mice treated orally with an extract from Prunella vulgaris
|
Fold change compared to vehicle-treated mdr1a-/- micea |
||||
| Gene | Pathway affiliation | FVBWT vehicle healthy | mdr1a-/-P. vulgaris healthy | mdr1a-/-P. vulgaris colitic |
| Ccl2 | NF-κB, LDL | -7.3 | -3.4 | -1.1 |
| Cxcl1 | NF-κB | -11.3 | -7.2 | -1.0 |
| Cxcl9 | NF-κB, Jak/Stat | -23.9 | -4.2 | -1.1 |
| Icam1 | NF-κB, Phospholipase C | -3.2 | -1.2 | 1.8 |
| Il1a | NF-κB | -13.4 | -8.0 | 1.3 |
| Mmp10 | NF-κB, Jak/Stat | -6.6 | -8.5 | 1.2 |
| TNFα | NF-κB | -10.2 | -2.6 | 1.2 |
| Vcam1 | NF-κB, Phospholipase C, LDL | -3.8 | -2.0 | 1.2 |
| Ccl20 | NF-κB | -3.6 | -2.0 | 1.4 |
| Il2 | NF-κB, NFAT, Calcium, PKC | -3.7 | -2.2 | -1.5 |
a
A negative value indicates that there was a lower level of gene expression when compared to the level of gene expression in vehicle-treated mdr1a-/- mice that developed severe colitis. P. vulgaris: Prunella vulgaris.