Table 3.
Relevant outcomes in pregnant women with diabetes receiving ILPS or NPH insulin in a multicenter retrospective cohort study [81]
| Patients | Insulin (N) | Age (years) | Mean BMIa, kg/m2 | Mean maternal HbA1c (trimester), % | Maternal outcomes, % patients | Pregnancy/fetal outcomes, % pregnancies | Mean fetal birth weight, g | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0b | 1st | 2nd | 3rd | Severe HG | HTNc | DKA | Cesarean section | Congenital malformation | Macrosomia | |||||
| GDM | ILPS (508) | 36.3 | 27.2 | NA | NA | NA | NA | 0 | 6.9 | 0 | 48.7 | 0 | 5.3 | 3295 |
| NPH (125) | 24.9 | 26.0 | NA | NA | NA | NA | 0 | 6.9 | 0 | 48.8 | 0 | 6.9 | 3423 | |
| T1D | ILPS (37) | 35.5 | 24.0 | 7.5 | 7.1 | 6.5 | 6.4 | 5.4 | 8.1 | 0 | 45.9 | 0 | 21.6 | 3550 |
| NPH (504) | 29.9 | 23.3 | 7.5 | 7.2 | 7.2 | 6.4 | 15.1 | 12.8 | 5.4 | 73.0 | 5.9 | 13.3 | 3300 | |
| T2D | ILPS (67) | 33.2 | 28.7 | 6.7 | 6.4 | 5.8 | 6.2 | 1.5 | 8.9 | 0 | 46.5 | 0 | 8.9 | 3235 |
| NPH (164) | 33.2 | 28.1 | 6.6 | 6.1 | 6.4 | 5.7 | 1.3 | 9.4 | 0 | 69.3 | 1.9 | 11.9 | 3200 | |
BMI body mass index, DKA diabetic ketoacidosis, GDM gestational diabetes, HbA1c glycated hemoglobin, HG hypoglycemia, HTN hypertension, ILSP insulin lispro protamine suspension, NA not available, NPH neutral protamine Hagedorn, T1D type 1 diabetes, T2D type 2 diabetes
aPrepregnancy maternal BMI
bPreconception period
cDuring pregnancy