Table 2. Multivariate analysis of prognostic factors for OS and EFS in 119 patients with MK-AML.

	Overall survival		Event-free survival
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (<60 years)	0.868 (0.540–1.397)	0.561	0.940 (0.609–1.449)	0.778
Single monosomy	0.460 (0.274–0.772)	0.003	0.514 (0.294–0.897)	0.019
Complex (⩾4 clonal abnormalities)	—		0.879 (0.481–1.607)	0.676
⩾10% Cells with normal metaphase	0.511 (0.311–0.841)	0.008	0.692 (0.447–1.071)	0.098
De novo AML	—		0.525 (0.297–0.930)	0.027
Absence of abn(17p)	0.532 (0.311–0.911)	0.022	0.708 (0.411–1.219)	0.213
Achievement of CR after induction Tx	0.238 (0.143–0.396)	<0.001	0.264 (0.168–0.416)	<0.001

Abbreviations: AML, acute myeloid leukemia; CI, confidence interval; CR, complete remission; EFS, event-free survival; HR, hazard ratio; MK, monosomal karyotype; OS, overall survival; Tx, therapy.