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. 2015 Oct 16;5(10):e361. doi: 10.1038/bcj.2015.89

Figure 2.

Figure 2

Frequency of chromatin modifying and organizing gene mutations in GCB lymphomas. Data from genome, exome and transcriptome sequencing studies of FL, BL and DLBCL with sufficient data quality9, 10, 11, 12, 13, 14, 15, 16, 17, 18 are summarized. Individual tumors are represented in columns and genes in rows. Colored bars indicate the presence of a somatic mutation and the percentage of tumors with mutations each gene are annotated to the right for each disease. Mutations of chromatin modifying and organizing genes are found in 84% (54/64) of FL tumors, 40% (62/155) of DLBCL tumors and 35% (29/82) of BL tumors. It should be noted, however, that DLBCL tumor are not divided by cell of origin subtypes within this diagram, and the majority of these mutations likely stratify within the GCB-like subtype. FLs are characterized by high frequencies of CREBBP and KMT2D mutations, DLBCLs are characterized by frequent mutations of HISTH1 family genes and EZH2, and BLs are characterized by high frequencies of SWI/SNF component (ARID1A, SMARCA4) mutations.