Table 4. Within group Spearman correlations between CSF biomarkers and hippocampal complex structure sizes.
| Spearman | Secondary control group | All-cause MCI | Poststroke |
|---|---|---|---|
| Hippocampus; rV | |||
| Aβ42a | rho=−0.071/P=0.365 | rho=0.356/P=0.006 | rho=0.313/P=0.056* |
| p-Taub | rho=−0.036/P=0.430 | rho=−0.171/P=0.196 | rho=0.304/P=0.061 |
| t-Tauc | rho=0.015/P=0.471 | rho=−0.283/P=0.03 | rho=0.210/P=0.146 |
| Presubiculum; rV | |||
| Aβ42 | rho=0.161/P=0.217 | rho=0.38/P=0.003 | rho=0.245/P=0.109 |
| p-Tau | rho=0.071/P=0.364 | rho=−0.171/P=0.195 | rho=0.239/P=0.115 |
| t-Tau | rho=0.117/P=0.285 | rho=−0.302/P=0.02 | rho=0.115/P=0.283 |
| Subiculum; rV | |||
| Aβ42 | rho=−0.046/P=0.411 | rho=0.334/P=0.010 | rho=0.145/P=0.235 |
| p-Tau | rho=0.096/P=0.320 | rho=−0.196/P=0.137 | rho=0.070/P=0.365 |
| t-Tau | rho=0.119/P=0.282 | rho=−0.261/P=0.046 | rho=0.079/P=0.347 |
| CA1; rV | |||
| Aβ42 | rho=−0.078/P=0.353 | rho=0.118/P=0.375 | rho=0.237/P=0.117 |
| p-Tau | rho=0.133/P=0.258 | rho=−0.199/P=0.131 | rho=−0.026/P=0.449 |
| t-Tau | rho=0.001/P=0.497 | rho=−0.192/P=0.145 | rho=0.111/P=0.291 |
| CA2/3; rV | |||
| Aβ42 | rho=−0.068/P=0.370 | rho=0.292/P=0.025 | rho=0.145/P=0.236 |
| p-Tau | rho=0.019/P=0.464 | rho=−0.197/P=0.134 | rho=0.062/P=0.379 |
| t-Tau | rho=0.076/P=0.353 | rho=−0.269/P=0.039 | rho=0.059/P=0.386 |
| CA4/DG; rV | |||
| Aβ42 | rho=−0.065/P=0.376 | rho=0.344/P=0.008 | rho=0.126/P=0.266 |
| p-Tau | rho=0.056/P=0.393 | rho=−0.185/P=0.16 | rho=0.096/P=0.316 |
| t-Tau | rho=0.109/P=0.298 | rho=−0.265/P=0.042 | rho=0.100/P=0.310 |
| Perirhinal cortex; mT | |||
| Aβ42 | rho=−0.134/P=0.257 | rho=0.032/P=0.810 | rho=−0.088/P=0.275 |
| p-Tau | rho=−0.164/P=0.211 | rho=−0.194/P=0.142 | rho=−0.031/P=0.438 |
| t-Tau | rho=−0.050/P=0.405 | rho=−0.164/P=0.215 | rho=0.238/P=0.116 |
| Entorhinal cortex; mT | |||
| Aβ42 | rho=−0.262/P=0.098 | rho=0.242/P=0.065 | rho=0.120/P=0.275 |
| p-Tau | rho=−0.324/P=0.053 | rho=−0.209/P=0.111 | rho=0.209/P=0.148 |
| t-Tau | rho=−0.241/P=0.117 | rho=−0.209/P=0.113 | rho=0.262/P=0.093 |
Abbreviations: Aβ42, amyloid β 1-42; CA, cornu ammonis; CSF, cerebrospinal fluid; mT, mean thickness; MCI, mild cognitive impairment; rV, relative volume. The analyses in this research question were performed in the secondary control group, the all-cause MCI group, and the poststroke group. Negative correlations are denoted with a minus (−).
a
Cerebrospinal fluid amyloid β 1-42.
b
Cerebrospinal fluid total Tau and p-Tau.
c
Cerebrospinal fluid phosphorylated Tau. Significant correlations are shown in bold.