Table 5. Within-group Spearman correlations between WMH load (corrected for age and gender) and neuropsychological function.
| Controls | Amyloid-positive MCI | Poststroke | |
|---|---|---|---|
| Memory | |||
| Word list memory; immediate recall (RAVLT) | rho=0.059/P=0.373 | rho=0.285/P=0.083 | rho=−0.324/P=0.053 |
| Word list memory; delayed recall (RAVLT) | rho=0.019/P=0.459 | rho=0.532/P=0.003 | rho=−0.182/P=0.187 |
| Story memory; immediate recall (WMS-R) | Data not available | rho=0.301/P=0.077 | rho=−0.303/P=0.066 |
| Story memory; delayed recall (WMS-R) | Data not available | rho=0.243/P=0.126 | rho=−0.303/P=0.066 |
| Psychomotor speed | |||
| D-KEFS Stroop 1 (Color naming) | rho=0.051/P=0.391 | rho=−0.464/P=0.010 | rho=−0.359/P=0.036 |
| D-KEFS Stroop 2 (Word reading) | rho=0.093/P=0.307 | rho=−0.318/P=0.061 | rho=−0.444/P=0.011 |
| Digit-symbol (WAIS-III) | Data not available | rho=−0.255/P=0.110 | rho=−0.323/P=0.054 |
| Executive functions | |||
| D-KEFS Stroop 3 (Color-Word response inhibition) | rho=0.216/P=0.117 | rho=−0.216/P=0.149 | rho=−0.026/P=0.450 |
| D-KEFS Stroop 4 (Color-Word Switching) | rho=−0.198/P=0.138 | rho=−0.69/P=0.374 | rho=−0.420/P=0.016 |
| Letter-number sequencing (WAIS-III) | rho=0.195/P=0.139 | rho=−0.437/P=0.015 | rho=−0.135/P=0.256 |
| General screening test | |||
| MMSE | rho=−0.20/P=0.128 | rho=0.052/P=0.402 | rho=−0.497/P=0.006 |
Abbreviations: D-KEFS, Delis-Kaplan Executive Function System; MCI, mild cognitive impairment; MMSE, mini-mental state examination; RAVLT, Rey Auditory Verbal Learning Test; WAIS-III, Wechsler Adult Intelligence Scale – Third Edition; WMS-R, Wechsler Memory Scale – Revised; WMH, white-matter hyperintensity. Neuropsychological measures (except MMSE) are normed (T scores). Negative correlations are denoted with a minus (−). Significant correlations are shown in bold.