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Effect of 20-hydroxyeicosatetraenoic acid (20-HETE) inhibition with HET0016 after resuscitation from 12 minutes of cardiac arrest (CA) on neurodegeneration. Treatment with HET0016 reduced cortical neurodegeneration at 48 hours versus vehicle. Hematoxylin and eosin sections from the parietal cortex of representative sham-, vehicle-, and HET0016-treated rats are illustrated. High power image insets of pyknotic neurons are included. *P<0.05.
