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. 2015 Jun 10;35(11):1771–1782. doi: 10.1038/jcbfm.2015.120

Figure 2.

Figure 2

Impact of reconstruction setting on reference region extraction. (A) Spatial distribution of the voxels selected via supervised clustering as a reference region with different Poisson ordered subset expectation maximization algorithm (POSEM) reconstruction settings (1 and 10 iterations, respectively) is shown. (B and C) The time courses of the regional activity obtained from different reconstructed positron emission tomography (PET) images, with POSEM 1-iteration and POSEM 10-iterations, respectively, are shown. Notably, the two reconstruction settings are associated with the highest and lowest image signal-to-noise ratio (SNR) (Figure 1). (D) The fraction of the gray matter (GM) voxels selected as a reference region as function of the reconstruction settings is reported. (E) The normalized TACs of the three kinetic classes used by the supervised clustering in comparison with the normalized reference region time-activity curves (TACs) obtained with POSEM 1-iteration (red line) and POSEM 10-iterations (blue line), respectively, are shown.