Figure 7.

Comparison between [¹¹C]PIB imaging and myelin-associated protein gene expressions. (A) The myelin-associated protein mRNA auto-correlations are shown. Probe selection and their spatial expression patterns are used as reported by the Allen Brain Atlas database (http://human.brain-map.org/). (B) Reports for the same probes the relative differences of mRNA expressions between white matter (WM) and gray matter (GM). (C) mRNA cross-correlation with myelin-associated templates obtained by using Poisson ordered subset expectation maximization algorithm (POSEM) 10 iterations with point spread function (PSF) smoothing reconstruction setting is shown. Black and gray bars refer to correlation with [¹¹C]PIB myelin maps using distribution volume ratio (DVR) and standardized uptake value (SUV), respectively.