Figure 2.

Effect of anesthesia on local field potential, single unit, and multi-unit activity responses. Peri-stimulus histograms of local field potential (A–C), single unit (D–F), and multi-unit activity (G–I) activity in the whisker barrel cortex averaged across subjects are shown before, during, and after fentanyl+isoflurane anesthesia. Responses are shown using both 100 ms (gray) and 1 second (black) bins. Local field potential and multi-unit activity was normalized to the baseline level before stimulus presentation and drug administration. All three measures of neural activity show a biphasic response characterized by initial peak (transient) followed by a plateau (sustained). Although fentanyl+isoflurane anesthesia produced little change in local field potentials peak, both baseline and plateau response decreased and subsequently recovered. Single unit and multi-unit activity baseline, peak, and plateau decreased with anesthesia and later recovered. The gray bar indicates the stimulus presentation.