Figure 4.

Effect of anesthesia on transient and sustained components of neuronal response. The local field potential (A) and single unit (B) peak and plateau responses to whisker stimulus during anesthesia are shown for each drug condition. Values are normalized to the level before anesthesia (100%) for each case. Peak response magnitude decreased for local field potential during fentanyl anesthesia, but increased in the presence of isoflurane, with the greatest change occurring under isoflurane alone. Local field potential plateau showed a consistent decrease for each drug condition. Single unit peak and plateau magnitude decreased for all anesthesia conditions, with the greatest change occurring under isoflurane+fentanyl. Error bars represent the s.e.m. Significant changes are indicated by brackets.