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. 2015 Jun 17;35(11):1827–1835. doi: 10.1038/jcbfm.2015.133

Figure 3.

Figure 3

Average time-activity curves (TACs) (SUV, standardized uptake value) in selected brain regions of baseline (open symbols in A) and PF-04457845 (PF) blocking (n=2 each at doses of 1, 4, and 20 mg, respectively; closed symbols in A) and test–retest (B, n=5) scans of [11C]CURB. *For illustrative purposes we are showing data acquired over 90 minutes; note that kinetic modeling was applied to data truncated at 60 minutes as per Rusjan et al.27 AMG, amygdala; Hippo, hippocampus; PFctx, prefrontal cortex; PUT, putamen.