Table 3. Test–retest reproducibility and reliability of λk 3 for [11C]CURB determined by a 2-TCMi (n=5).
| 60 minutes | Test mean (s.d.) | Retest mean (s.d.) | Mean | BSSD (%CV) | WSSD (%CV) | TRV% (SD%) | ICC |
|---|---|---|---|---|---|---|---|
| λk3 | |||||||
| Prefrontal ctx | 0.148 (0.027) | 0.153 (0.023) | 0.150 | 0.024 (16) | 0.010 (6) | 9 (7) | 0.770 |
| Temporal ctx | 0.161 (0.028) | 0.164 (0.025) | 0.152 | 0.025 (16) | 0.008 (5) | 6 (5) | 0.869 |
| Occipital ctx | 0.153 (0.029) | 0.155 (0.022) | 0.154 | 0.025 (16) | 0.009 (6) | 8 (7) | 0.798 |
| Parietal ctx | 0.163 (0.028) | 0.166 (0.025) | 0.164 | 0.025 (15) | 0.009 (5) | 7 (7) | 0.795 |
| A. cingulate | 0.158 (0.029) | 0.162 (0.026) | 0.160 | 0.025 (16) | 0.011 (7) | 11 (8) | 0.732 |
| Insular ctx | 0.165 (0.028) | 0.167 (0.029) | 0.166 | 0.027 (16) | 0.007 (4) | 5 (6) | 0.885 |
| Cerebellar ctx | 0.158 (0.029) | 0.169 (0.030) | 0.163 | 0.028 (17) | 0.011 (7) | 9 (8) | 0.781 |
| Hippocampus | 0.158 (0.023) | 0.161 (0.026) | 0.159 | 0.023 (15) | 0.06 (4) | 5 (7) | 0.853 |
| Amygdala | 0.135 (0.026) | 0.138 (0.027) | 0.136 | 0.022 (16) | 0.015 (11) | 15 (8) | 0.546 |
| Caudate | 0.147 (0.035) | 0.142 (0.022) | 0.144 | 0.027 (19) | 0.012 (8) | 11 (8) | 0.740 |
| Putamen | 0.163 (0.036) | 0.167 (0.027) | 0.165 | 0.030 (18) | 0.009 (6) | 8 (10) | 0.824 |
| Thalamus | 0.181 (0.030) | 0.179 (0.035) | 0.180 | 0.032 (18) | 0.008 (5) | 7 (6) | 0.894 |
| All areas included | 9 (7) | 0.793 | |||||
2-TCMi, irreversible two-tissue compartment model; A. cingulate, anterior cingulated cortex; BSSD, between-subject standard deviation; ctx, cortex; CV, %standard deviation/mean; ICC, intraclass correlation coefficient; TRV, test–retest variability—the mean across the subjects of the ratio (%) of absolute value of the difference between test-retest to the average of test–retest; WSSD, within-subject standard deviation.