Figure 3.

The time course of ischemia-induced diffusion changes indicated by changes in the ratio of apparent diffusion coefficient (rADC) shows a typical minimal reduction around days 2 to 3 with a slow recovery to day 10. Insets show representative DWI images showing a selective affection of the CA1 region including swelling of this region (Pat 1 to 3). Insets show corresponding ADC maps. Pat 4 shows a small dot-like lesion in CA1 after a multiembolic stroke. Notably, Pat 2 shows the affection of the complete bilateral hippocampi with a reduced rADC but with a preferential affection of the CA1 region. Data expressed as mean±s.d. as well shown as individual values (black dots). Post hoc comparisons (t-test) of ADC between time periods show that during the acute phase at day 3, ADC was at its minimum and significantly reduced compared with day 1 as well as to the normalization phase after day 7. *P<0.05, **P<0.01. Pat, patient.