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. 2015 Jul 1;35(11):1711–1721. doi: 10.1038/jcbfm.2015.149

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Copyright © 2015 International Society for Cerebral Blood Flow & Metabolism, Inc.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Micro single photon emission computed tomography (μSPECT) of relative cerebral blood flow (rCBF) 24 hours after transient middle cerebral artery occlusion (tMCAo) using [^99mTc]hexamethylpropyleneamine oxime ([^99mTc]HMPAO). [^99mTc]HMPAO μSPECT was acquired in n=14 animals 24 hours after tMCAo. T2-weighted (T2w) micro magnetic resonance imaging (μMRI) was conducted 14 days after tMCAo in the same animals to determine the infarct volume. (A) Representative images of two examples with different degrees of perfusion deficit and their corresponding T2w-μMR images 14 days after tMCAo. Color scales were adjusted and normalized to the injected activity (MBq). Data are expressed as standardized uptake values (SUVs). (B) Depending on the perfusion deficit after 24 hours, varying degrees of infarct volumes were measured. The percentage of remaining ipsilateral relative cerebral blood flow (rCBF) (24 hours after tMCAo) was negatively correlated with the ischemic volume (percentage of whole brain) 14 days after tMCAo (Spearman correlation analysis; R²=−0.66; P<0.010, n=14).