Table 2. Main pharmacokinetic properties of phenacetin, tolbutamide, chlorzoxazone, and midazolam in rat plasma after a cocktail solution administration.
| Parameter | t1/2 (h) | Tmax (h) | Cmax (μg/L) | AUC0-∞ (μg·h/L) | MRT0-∞ (h) | CLz/F (L/h/kg) |
|---|---|---|---|---|---|---|
| Phenacetin | ||||||
| Control | 2.06±0.65 | 0.25±0.07 | 6,728.3±52.4 | 10,971.1±238.4 | 1.37±0.41 | 1.641±0.469 |
| Smoking | 0.75±0.10* | 0.26±0.02 | 4,940.0±18.0* | 7,451.6±123.9* | 1.50±0.24 | 2.209±0.494* |
| Tolbutamide | ||||||
| Control | 16.81±2.37 | 2.63±0.60 | 18,425.0±6,409.6 | 449,565.0±70,733.9 | 24.79±9.37 | 0.008±0.002 |
| Smoking | 23.46±6.92* | 2.58±0.15 | 27,766.7±6,833.1* | 658,288.6±33,820.6* | 34.25±4.70* | 0.005±0.001* |
| Chlorzoxazone | ||||||
| Control | 2.13±0.33 | 0.26±0.00 | 9,287.5±1,925.2 | 19,899.7±394.0 | 2.17±0.82 | 1.129±0.403 |
| Smoking | 2.32±0.60 | 0.25±0.00 | 11,396.7±567.7 | 20,978.0±398.4 | 1.96±0.51 | 1.162±0.590 |
| Midazolam | ||||||
| Control | 1.69±0.34 | 0.25±0.00 | 974.8±70.4 | 1,447.4±48.8 | 1.75±0.49 | 9.089±0.614 |
| Smoking | 2.60±0.68* | 0.29±0.10 | 1,808.3±83.6* | 2,237.1±50.5* | 3.31±0.82* | 5.376±0.204* |
Values are expressed as mean ± SD, n=6. AUC0-∞, area under concentration-time curve extrapolated to infinity, t1/2 elimination half-time, Tmax time to maximum concentration, Cmax maximum concentration, MRT0-∞ mean residence time extrapolated to infinity, CL/F apparent clearance. *, P<0.05 vs. control.