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Effects of HMGB1 signaling on the airway hyperresponsiveness (AHR) of acute allergic asthma. Mice from asthma group showed high RL and low Cdyn in MCh response compared to control mice. Blockade of HMGB1 markedly improved AHR to MCh. Three mice were analyzed in each study group. *, P<0.01 asthma group versus control group; #, P<0.01, anti-HMGB1 group versus HMGB1 group. RL, resistance of lung; BALF, bronchoalveolar lavage fluid; HMGB1, high mobility group box 1; MCh, methacholine.
