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. 2015 Oct;7(10):1732–1741. doi: 10.3978/j.issn.2072-1439.2015.10.18

Figure 5.

Figure 5

Histological analysis of lung sections. (A-D) Representative results for histological analysis of inflammatory infiltration, and (E-H) representative results for mucus secretion. OVA aerosol challenge induced marked inflammatory infiltration on the peribronchiolar and perivascular connective tissues (B) as compared with that control mice (A). Administration of HMGB1 aggravated inflammatory infiltration (C), while administration of anti-HMGB1 monoclonal antibody almost abrogated HMGB1 mediated effect (D). In consistent with the severity of inflammatory infiltration, asthmatic mice showed marked goblet cell hyperplasia and mucus hypersecretion (F) compared to mice from control group (E). Similarly, HMGB1 could promote mucus production (G) and anti-HMGB1 could attenuate its effect (H).Quantitative analysis of inflammatory infiltration (I) and mucus production (J). *, P<0.01 versus control group; #, P<0.05 versus asthma group; **, P<0.01 versus HMGB1 group. HMGB1, high mobility group box 1.