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. 2015 Oct;7(10):1787–1797. doi: 10.3978/j.issn.2072-1439.2015.10.41

Figure 3.

Figure 3

AA administration prevented pressure overload-induced cardiac hypertrophy. Mice were subjected to TAC and treated with AA (100 mg/kg/daily) or with the vehicle for 2 weeks, the age-matched sham surgical operated mice served as control. (A) Representative images of hearts showing TAC-induced cardiac hypertrophy and the ratio of HW/BW; (B) heart sections were counterstained with H&E, representative photographs demonstrating cardiac hypertrophy of heart sections from each group are shown. ×400 (n=3 mice/group); (C) the cardiomyocyte cross-sectional area; (D) the levels of ANP mRNA expression; (E) the levels of IL-1β mRNA expression; (F) the levels of IL-1β protein expression. n=10 mice/group, ***P <0.001 vs. sham group; ##P<0.01 and ###P<0.001 vs. TAC group. AA, asiatic acid; TAC, transverse aortic constriction; HW, heart weight; BW, body weight; H&E, hematoxylin and eosin; ANP, atrial natriuretic peptide; IL, interleukin.