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AA prevented TAC-induced increase in NF-κB binding activity in the myocardium. Mice were subjected to TAC and treated with AA (100 mg/kg/daily) or with the vehicle for 2 weeks, the age-matched sham surgical operated mice served as control. The levels of NF-κB binding activity was determined by EMSA. n=10 mice/group, ***P<0.001 vs. sham group; ###P<0.001 vs. TAC group. AA, asiatic acid; TAC, transverse aortic constriction; NF, nuclear factor; EMSA, electrophoretic mobility shift assay.
