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. 2015 Nov;71(5):544–552. doi: 10.1016/j.jinf.2015.07.007

Figure 3.

Figure 3

Geo-temporal distribution of isolates within distal sublineages of meningococcal lineage 11.1. The inset (top-right) depicts a cgMLST (1546 loci) Neighbour-net phylogenetic network of all 750 geo-temporally diverse cc11 isolates and two non-cc11 isolates (cc8 and cc41/44) highlighting the distal region of lineage 11.1 that bifurcates into two sublineages. Isolates corresponding to this region underwent a separate cgMLST (1546 loci) comparison to generate the Neighbour-net network in the main figure. Both sublineages contained several clusters, each relating to a noteworthy episode of serogroup W disease. One lineage included strains relating to the Hajj outbreak of 2000 onwards (Anglo-French Hajj strain), the expansion of endemic MenW:cc11 disease in South Africa from 2003 (endemic South African Strain) and a period of MenW:cc11 epidemics in sub-Saharan Africa (Burkina Faso/North African Strains). The other sublineage contained clusters relating to expanding endemic MenW:cc11 disease in South America and the UK (the South American/UK strain). Dots relate to individual cases. The scale bar indicates the number of loci differing among the 1546 compared.